RESEARCH LIBRARY

Peptide science with the receipts. Compound mechanisms, trial breakdowns, and lab method, cited to the primary literature.

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Compound Deep Dive

Retatrutide Phase 2 Trial Breakdown: What the 2023 NEJM Data Actually Showed

The 48-week Phase 2 results for the triple-hormone-receptor agonist that documented the largest weight reduction of any single compound in clinical trials.

Axiom Research Team|Apr 22, 2026|10 min read

Reading a Peptide Certificate of Analysis: The Numbers That Matter

A line-by-line guide to interpreting COAs — purity percentages, mass spec data, net peptide content, and the red flags to watch for.

Axiom Research Team|Apr 6, 2026|8 min read

What Are Research Peptides? A Complete Beginner's Guide

Everything you need to know about peptide chemistry, classification, and the current research landscape.

Axiom Research Team|Mar 15, 2026|8 min read

FDA Status of Research Peptides: 503A, 503B, Approved, and Research-Only

A practical guide to understanding the regulatory categories that govern peptide compounds in the United States — and what each status actually means.

Axiom Research Team|May 20, 2026|8 min read

Compound Deep Dive

Sermorelin: The Original GHRH Analog and Its Clinical Legacy

A 29-amino-acid GHRH(1-29) fragment with FDA approval history, decades of pediatric clinical use, and a unique position in the GH secretagogue landscape.

Axiom Research Team|May 18, 2026|7 min read

Compound Deep Dive

Thymosin Alpha-1: The Most Clinically Validated Immune Peptide

A naturally occurring 28-amino-acid peptide with regulatory approvals in over 30 countries — and one of the most extensive clinical track records in peptide research.

Axiom Research Team|May 16, 2026|8 min read

Compound Deep Dive

Mitochondrial Peptides: MOTS-c, Humanin, and Elamipretide

Three peptides from a research field that did not exist 25 years ago — mitochondrial-derived peptides, their roles in aging biology, and what early clinical translation looks like.

Axiom Research Team|May 14, 2026|10 min read

Compound Deep Dive

GHK-Cu: 50 Years of Copper Peptide Research and What the Literature Documents

A tripeptide with documented effects on skin regeneration, gene expression, and tissue repair — and a research track record that spans the field of bioactive peptides.

Axiom Research Team|May 12, 2026|9 min read

Compound Deep Dive

DSIP: Delta Sleep-Inducing Peptide and the Sparse Modern Literature

A historically significant peptide with substantial 1970s-1980s research and minimal modern follow-up — and what that pattern reveals about peptide research priorities.

Axiom Research Team|May 10, 2026|7 min read

Compound Deep Dive

Epitalon and Telomere Research: Separating the Evidence from the Hype

A look at the pineal-derived tetrapeptide with documented effects on telomerase activity, gene expression, and animal lifespan — and what remains unresolved.

Axiom Research Team|May 8, 2026|9 min read

Compound Deep Dive

Cerebrolysin: Four Decades of Neurological Research and What the Evidence Shows

A porcine brain-derived peptide preparation with one of the longest clinical track records in neurological research — and the methodological questions that come with it.

Axiom Research Team|May 6, 2026|9 min read

Compound Deep Dive

Selank: The Tuftsin Analog and What the Anxiolytic Research Documents

A synthetic heptapeptide derived from the immunomodulatory tuftsin, with documented effects on anxiety, immunity, and enkephalin metabolism.

Axiom Research Team|May 4, 2026|8 min read

Compound Deep Dive

Semax Mechanism Deep Dive: BDNF, Melanocortin Signaling, and Nootropic Research

A look at the synthetic ACTH(4-10) analog with documented effects on neurotrophic factor expression and central nervous system signaling.

Axiom Research Team|May 2, 2026|8 min read

Compound Deep Dive

AOD-9604: The Growth Hormone Fragment Story

A look at the C-terminal hGH fragment with documented lipolytic activity in animal models — and what its failed human trials reveal.

Axiom Research Team|Apr 30, 2026|7 min read

Compound Deep Dive

Cagrilintide and the Amylin Story: Combination Research with Semaglutide

How a long-acting amylin analog adds a complementary mechanism to GLP-1 agonism — and what the CagriSema trial data shows.

Axiom Research Team|Apr 28, 2026|8 min read

Compound Deep Dive

Retatrutide Trial Landscape: 20 Active Studies and What They Are Investigating

A guide to the active Phase 1, 2, and 3 retatrutide trials — including the populations, endpoints, and timeline for the next generation of human data.

Axiom Research Team|Apr 26, 2026|9 min read

Compound Deep Dive

Retatrutide vs Tirzepatide vs Semaglutide: Head-to-Head Literature Comparison

A side-by-side look at three generations of incretin-based research compounds — single, dual, and triple receptor agonism — and what the trial data documents.

Axiom Research Team|Apr 24, 2026|10 min read

Compound Deep Dive

Tesamorelin: The Only FDA-Approved GHRH Analog and What That Means

How a single regulatory approval shapes our understanding of what GHRH-class compounds can do in human research populations.

Axiom Research Team|Apr 20, 2026|7 min read

Compound Deep Dive

CJC-1295 with DAC: Albumin Binding and the Long-Acting GHRH Analog

A detailed look at the drug affinity complex chemistry that extends GHRH half-life from minutes to days — and what the clinical data documents.

Axiom Research Team|Apr 18, 2026|8 min read

Compound Deep Dive

GHRH Analogs vs Ghrelin Mimetics: Two Pathways, Two Mechanisms

A side-by-side comparison of the two main classes of growth hormone secretagogues and why combination protocols are the standard in the literature.

Axiom Research Team|Apr 16, 2026|9 min read

Compound Deep Dive

MGF: Mechano Growth Factor and the IGF-1 Splice Variant Story

How mechanical stress on muscle produces a unique IGF-1 isoform — and what the literature documents about its role in muscle research.

Axiom Research Team|Apr 14, 2026|8 min read

Compound Deep Dive

KPV: The Melanocortin Tripeptide and Its Anti-Inflammatory Research

The smallest active fragment of α-MSH and what the literature documents about its activity in gut inflammation and immune signaling.

Axiom Research Team|Apr 12, 2026|8 min read

Compound Deep Dive

TB-500: Thymosin Beta-4, Actin Biology, and the Cell Migration Story

A focused look at TB-500 separate from BPC-157 — the actin-sequestering protein, the active fragment, and what the literature actually documents.

Axiom Research Team|Apr 10, 2026|9 min read

Compound Deep Dive

BPC-157 Mechanism Deep Dive: Angiogenesis, Nitric Oxide, and Growth Factor Cascades

A pathway-by-pathway look at what the preclinical literature suggests BPC-157 actually does at the molecular level.

Axiom Research Team|Apr 8, 2026|10 min read

Practical Guide

How Research Peptides Are Made: Synthesis, HPLC, and Mass Spectrometry

The chemistry behind solid-phase peptide synthesis and the analytical methods that verify what is in the vial.

Axiom Research Team|Apr 4, 2026|9 min read

Fundamentals

Peptide Research Evidence Hierarchies: From In Vitro to Human Trials

How to weigh in vitro experiments, animal models, and human clinical data when reading peptide literature.

Axiom Research Team|Apr 2, 2026|8 min read

Practical Guide

Understanding Peptide Storage, Reconstitution, and Handling

A practical guide to maintaining peptide integrity from purchase through research use.

Axiom Research Team|Mar 24, 2026|7 min read

Compound Deep Dive

Growth Hormone Secretagogues: Ipamorelin, CJC-1295, and GHRP Peptides

Understanding the two pathways of GH stimulation and how different secretagogues compare.

Axiom Research Team|Mar 22, 2026|9 min read

Compound Deep Dive

BPC-157 and TB-500: The Science Behind the Healing Stack

Examining the research literature on two of the most studied repair-associated peptides.

Axiom Research Team|Mar 20, 2026|9 min read

Compound Deep Dive

GLP-1 Agonists Explained: Semaglutide, Tirzepatide, and Beyond

A deep dive into the science behind GLP-1 receptor agonists and what clinical research has demonstrated.

Axiom Research Team|Mar 18, 2026|10 min read