MOTS-c

MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA. It acts as a mitochondrial signaling molecule that regulates metabolic homeostasis. Animal studies show improved insulin sensitivity and metabolic function. Limited human data exists.

PubMed results: 228 · Human studies: 131 · Animal studies: 178

Ranges reflect protocols studied in published research and animal-model extrapolation. Presented for research purposes only, not a recommendation or instruction for human use.

• Subcutaneous — standard range 5-10 mg, 3 times per week

Unknown (low confidence)

• NCT06133946 — Cohort Of DEafness-gene Screening, status: ACTIVE_NOT_RECRUITING. Indications: Hearing Loss
• NCT04013568 — Exercise Post-Diagnosis of Breast Cancer (NA), status: ACTIVE_NOT_RECRUITING. Indications: Breast Cancer
• NCT03878706 — The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination, status: RECRUITING. Indications: Diabetes Mellitus, Type 2
• NCT06500975 — Long Term Outcomes After Vestibular Implantation (NA), status: RECRUITING. Indications: Bilateral Vestibular Hypofunction, Bilateral Vestibular Deficiency, Bilateral Vestibulopathy, Gentamicin Ototoxicity, Aminoglycoside Toxicity, Vestibular Diseases, Sensation Disorders, Labyrinth Diseases, Other Disorders of Vestibular Function
• NCT07438002 — Analysis of Effects of High-intensity Physical Exercise in Subjects With Dialyzed Chronic Kidney Disease and in Conservative Treatment (NA), status: RECRUITING. Indications: Chronic Kidney Disease
• NCT04027712 — Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD, status: UNKNOWN. Indications: Diabetes, Clopidogrel Resistance, Amyloid, Insulin Resistance