Melanotan II safety profile — what 30 years of research shows

Sunless tanning is the headline application but the safety database has some real concerns. Spontaneous regression of melanocytic nevi has been documented in long-term users. Cardiovascular effects from non-selective melanocortin activity. Nausea, flushing.

The 1996 Phase 1 trial is historically interesting but the research community has accumulated a lot of post-marketing-style data since then that isn't always discussed.