HCG / Human Chorionic Gonadotropin

Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone produced by the placenta during pregnancy. Structurally similar to LH, it stimulates testosterone production in males and supports corpus luteum function in females. FDA-approved for fertility treatment and male hypogonadism.

PubMed results: 153 · Human studies: 99 · Animal studies: 111

Ranges reflect protocols studied in published research and animal-model extrapolation. Presented for research purposes only, not a recommendation or instruction for human use.

FDA-approved dosing varies by indication

• Intramuscular/Subcutaneous Injection — standard range 1000-2500 IU, 2-3 times weekly (hypogonadism)

24-36 hours (high confidence)

• NCT03682614 — Effect of Intrauterine Injection of HCG on Clinical Pregnancy Outcome in Repeated Implantation Failure Patients (NA), status: COMPLETED. Indications: Infertility
• NCT02420704 — Effect of Endometrial Thickness on IVF Outcome, status: UNKNOWN. Indications: Infertility
• NCT04407871 — Acupuncture and Chinese Herbal Medicine to Improve Live Birth Rate of in Vitro Fertilization (IVFAct) (NA), status: UNKNOWN. Indications: In Vitro Fertilization
• NCT00696800 — A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787) (PHASE3), status: COMPLETED. Indications: In Vitro Fertilization
• NCT03712683 — Thyroxin in Subclinical Hypothyroidism (NA), status: COMPLETED. Indications: Sub Clinical Hypothyroidism, Pregnancy Loss
• NCT01882166 — Time-lapse Monitoring of Early Embryo Development After Ovarian Stimulation During Infertility Treatment (NA), status: TERMINATED. Indications: Infertility, Female
• NCT06913075 — FET in Adenomyosis (NA), status: NOT_YET_RECRUITING. Indications: Adenomyosis
• NCT01714882 — Stress Management for Couples Undergoing In Vitro Fertilization (IVF) (PHASE2), status: COMPLETED. Indications: Infertility
• NCT03115320 — Frozen-thawed Embryo Transfer in a Natural Cycle: hCG Triggering Versus LH Home Test (PHASE4), status: TERMINATED. Indications: Infertility
• NCT04297553 — Fresh Versus Freeze-only After CAPA IVM on PCOS Patients (NA), status: COMPLETED. Indications: PCOS, IVM, Embryo Transfer
• NCT05586802 — Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome (PHASE3), status: RECRUITING. Indications: Klinefelter Syndrome
• NCT06026553 — Assessing Ketorolac (Toradol) at Oocyte Retrieval (PHASE1), status: UNKNOWN. Indications: Infertility, Infertility, Female, Oocyte Retrieval, Postoperative Pain, Embryo Transfer
• NCT01856062 — Ovulation Induction With Clomiphene Citrate and Dexamethasone (PHASE4), status: UNKNOWN. Indications: Infertility
• NCT01094496 — A Study of the CDX-1307 Vaccine Regimen in Patients With Newly Diagnosed Muscle-Invasive Bladder Cancer (The "N-ABLE" Study) (PHASE2), status: TERMINATED. Indications: Bladder Cancer
• NCT01468441 — Ovarian Stimulation Using Recombinant Follicle-stimulating Hormone (FSH) and Gonadotrophin Releasing Hormone (GnRH) Agonist in Alternate Days (NA), status: COMPLETED. Indications: Infertility
• NCT02357095 — UACE Followed by Uterine Suction Curettage for the Treatment of Caesarean Scar Pregnancy (NA), status: COMPLETED. Indications: Caesarean Scar Pregnancy
• NCT06228131 — Detection of hCG in Early Pregnancy Clinical Samples, status: COMPLETED. Indications: Early Pregnancy
• NCT01910766 — Coenzyme Q10 and Clomiphene Citrate (CC) for Ovulation Induction in Polycystic Ovary Syndrome (NA), status: COMPLETED. Indications: Polycystic Ovary Syndrome
• NCT04855383 — Intramuscular Injection of Human Chorionic Gonadotropin in Frozen Embryo Transfer Cycles (NA), status: COMPLETED. Indications: Embryo Implantation
• NCT00920361 — Designated Drug Use Investigation 1 of Follistim Injection (Study P06130)(COMPLETED), status: COMPLETED. Indications: Fertilization in Vitro