AOD-9604

AOD-9604 is a synthetic analog of the lipolytic domain of human growth hormone (hGH 177-191). It was originally developed as an anti-obesity drug. Animal studies showed lipolytic effects, but human trials failed to show significant weight loss. It does not raise IGF-1 levels.

PubMed results: 10 · Human studies: 10 · Animal studies: 10

Ranges reflect protocols studied in published research and animal-model extrapolation. Presented for research purposes only, not a recommendation or instruction for human use.

• Subcutaneous — standard range 300-600 mcg, Once daily

Unknown in humans (low confidence)

• Lipolytic domain of hGH fragment research (Strong preclinical): AOD-9604 is a synthetic analog of the C-terminal lipolytic region of human growth hormone (hGH 177-191); animal studies reported enhanced lipolysis and reduced lipogenesis without classic GH anabolic signaling.
• Minimal IGF-1 elevation relative to intact GH (Moderate clinical): Research indicates AOD-9604 does not meaningfully raise circulating IGF-1 levels, distinguishing its endocrine profile from intact growth hormone in clinical observations.
• Obesity drug development history (Limited): Human trials of AOD-9604 as an anti-obesity candidate failed to demonstrate significant weight loss, so clinical body-composition efficacy remains unproven despite earlier preclinical signals.

• Generally well-tolerated in trial reports — Mild, Not established. Published clinical development for obesity reported a relatively favorable tolerability profile overall, without a widely characterized unique toxicity signature.
• Injection-site reactions — Mild, Anecdotal. Local injection-site findings are discussed in peptide research settings; frequency specific to AOD-9604 is not firmly established in large post-marketing datasets.

• Known hypersensitivity to growth-hormone fragment analogs (Theoretical / Preclinical): Structural relation to hGH C-terminal sequences supports theoretical caution where prior hypersensitivity is documented.
• Pregnancy (Theoretical / Preclinical): Insufficient reproductive safety data for AOD-9604 support theoretical exclusion of pregnancy research contexts.

Lyophilized (powder): Refrigerated (2-8°C), Up to 24 months. Light sensitive: yes, store dark

Reconstituted (solution): Refrigerated (2-8°C), 4-6 weeks. Solvent: Bacteriostatic water