MOTS-c is wildly underrated for muscle research

Mitochondrial-derived peptide, declines with age, modulates myostatin signaling. The 2021 paper showed clear muscle atrophy attenuation in animal models.

Feels like everyone fixates on growth hormone secretagogues for muscle and forgets there's an entire class of mitochondrial peptides that probably matters more for actual muscle health in aging populations. The clinical translation is just slower because the field is newer.