Epitalon

Epitalon (Epithalon) is a synthetic version of Epithalamin, a peptide originally isolated from the pineal gland. Russian research claimed it activates telomerase and extends telomeres, potentially slowing aging. However, independent replication is limited and most evidence comes from animal studies and small Russian trials.

PubMed results: 60 · Human studies: 21 · Animal studies: 57

Ranges reflect protocols studied in published research and animal-model extrapolation. Presented for research purposes only, not a recommendation or instruction for human use.

• Subcutaneous — standard range 5-10 mg, Once daily. 10-20 days per course

~20 minutes (low confidence)

• Telomerase activation research (Limited): Russian research programs claimed that epitalon (epithalon), a synthetic analog of pineal peptide epithalamin, can activate telomerase and influence telomere length in experimental models; independent replication remains limited
• Pineal and circadian pathway research (Limited): As a synthetic pineal-related tetrapeptide, studies have examined epitalon in relation to pineal function, melatonin-related pathways, and age-associated endocrine patterns, primarily in animal and small historical trials
• Longevity and aging biomarker hypotheses (Theoretical): Preclinical and early clinical literature from limited sources has explored effects on aging-related biomarkers; human evidence quality is constrained by small sample sizes and limited modern controlled trials

• No robust documented human adverse profile — Mild, Not established. Published human safety datasets for epitalon are sparse relative to approved pharmaceuticals; formal adverse-event rates are not well established in modern controlled literature
• Injection site reactions (research contexts) — Mild, Anecdotal. When studied as a peptide preparation, local injection-site reactions are theoretically possible though systematically reported rates are limited

• Active malignancy (theoretical concern) (Theoretical / Preclinical): Hypotheses around telomerase activation raise theoretical concern about supporting cellular proliferative capacity; this remains theoretical without robust clinical confirmation
• Insufficient modern clinical safety characterization (Theoretical / Preclinical): Limited independent human data and mixed quality of historical studies mean firm clinical contraindications beyond general research cautions are not established

Lyophilized (powder): Refrigerated (2-8°C), Up to 24 months. Light sensitive: yes, store dark

Reconstituted (solution): Refrigerated (2-8°C), 4-6 weeks. Solvent: Bacteriostatic water