GHK-Cu

GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. Found in human plasma, it has been shown to have various effects on gene expression related to tissue repair, remodeling, and anti-inflammatory processes. It is used in cosmetic and wound healing applications.

PubMed results: 64 · Human studies: 28 · Animal studies: 38

Ranges reflect protocols studied in published research and animal-model extrapolation. Presented for research purposes only, not a recommendation or instruction for human use.

Based on topical and limited systemic studies

• Topical — standard range 0.5-2% solution, Once or twice daily

30-60 minutes (low confidence)

• Wound healing (Human clinical data): Demonstrated effects on wound healing and tissue remodeling

• Local skin irritation or mild erythema — Mild, Uncommon. Topical and wound-research applications of GHK-Cu have occasionally been associated with mild local irritation or transient erythema; systemic adverse rates in published literature are generally low
• Copper-related sensitivity (rare theoretical) — Mild, Rare. As a copper–tripeptide complex, research contexts note theoretical sensitivity in individuals with copper intolerance, though documented serious reactions in cosmetic and wound-healing literature remain uncommon

• Wilson disease or disorders of copper overload (Theoretical / Preclinical): Because GHK-Cu delivers bioavailable copper in complexed form, research frameworks typically exclude populations with impaired copper handling or established copper overload disorders
• Known hypersensitivity to copper peptide complexes (Clinical): Documented allergy or hypersensitivity to copper peptide formulations is a standard exclusion in cosmetic and dermatologic research protocols

Lyophilized (powder): Refrigerated (2-8°C), Up to 24 months. Light sensitive: yes, store dark

Reconstituted (solution): Refrigerated (2-8°C), 4-6 weeks. Solvent: Bacteriostatic water

• NCT07437586 — Topical GHK-Cu Gel for Acute Skin Wound Healing (PHASE2), status: RECRUITING. Indications: Acute Standardized Cutaneous Wounds (Punch-biopsy Wounds)
• NCT05932732 — Trial Assessing the Impact on Facial Skin Quality, Hydration, and Skin Barrier of Three (3) Hydrafacial Treatments in Adults of All Skin Types. (PHASE4), status: COMPLETED. Indications: Cutis Laxa Facialis, Xeroderma

Gly-His-Lys-Cu