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A 44-amino-acid peptide hormone produced by the hypothalamus that stimulates growth hormone release from the anterior pituitary. GHRH acts through the GHRH receptor (GHRH-R) and its signaling represents one of the primary mechanisms controlling GH secretion. Synthetic GHRH analogs like CJC-1295 and modified GRF (1-29) have been developed with enhanced stability and longer half-lives compared to native GHRH for research applications.