Somatostatin

A peptide hormone that inhibits the release of growth hormone, insulin, glucagon, and several other hormones. Produced in the hypothalamus, gastrointestinal tract, and pancreas, somatostatin acts as a regulatory brake on hormone secretion throughout the body. Understanding somatostatin's inhibitory role is critical in GH secretagogue research, as it explains the pulsatile nature of GH release and why certain secretagogues are more effective when administered during somatostatin troughs.