CJC-1295 w/ DAC

CJC-1295 with DAC incorporates a drug affinity complex (DAC) that binds to serum albumin, dramatically extending its half-life from 30 minutes to 5-8 days. This allows for weekly dosing. However, extended half-life may cause GH bleed rather than pulses, which may affect the natural GH secretion pattern.

PubMed results: 0 · Human studies: 0 · Animal studies: 0

Ranges reflect protocols studied in published research and animal-model extrapolation. Presented for research purposes only, not a recommendation or instruction for human use.

Based on pharmacokinetic studies

• Subcutaneous Injection — standard range 1000-2000 mcg, Once weekly

5.8-8.1 days (high confidence)

• Sustained growth hormone elevation via albumin binding (Limited): CJC-1295 with DAC incorporates a drug affinity complex that binds serum albumin, extending half-life to roughly 5–8 days in research descriptions and supporting prolonged GH-axis stimulation relative to short-acting GHRH analogs
• Reduced administration frequency in research protocols (Limited): Extended pharmacokinetic profile has been studied as a basis for less frequent dosing schedules compared with non-DAC GHRH analogs that clear within about 30 minutes
• GHRH receptor agonism (Strong preclinical): Research frames CJC-1295 as a modified GHRH analog that stimulates pituitary GH release through GHRH receptor pathways

• Water retention and related GH-axis effects — Mild, Anecdotal. Anecdotal and limited clinical observations around prolonged GH elevation include fluid retention and related soft-tissue effects, consistent with broader GH secretagogue research
• Injection site reactions — Mild, Anecdotal. Subcutaneous research use is associated with local injection-site reactions in anecdotal reports; formal human adverse-event datasets remain limited

• Active malignancy (Theoretical / Preclinical): Sustained GH and IGF-1 pathway stimulation raises theoretical concern about growth-promoting effects in active neoplastic disease, a common caution in GH-axis research compounds
• Concern for non-pulsatile GH elevation (Theoretical / Preclinical): Research commentary notes that multi-day half-life may produce continuous GH elevation rather than physiologic pulses, which may alter natural GH secretion patterns

Lyophilized (powder): Refrigerated (2-8°C), Up to 24 months. Light sensitive: yes, store dark

Reconstituted (solution): Refrigerated (2-8°C), 4-6 weeks. Solvent: Bacteriostatic water